Improve Health And Wellness With Resveratrol
Resveratrol is considered a type of polyphenol called a phytoalexin, a class of compounds produced as part of a plant’s defense system against disease. Red wine contains high levels of resveratrol, as do grapes, raspberries, peanuts, and numerous other plants.
It also belongs to a class of polyphenolic compounds called stilbenes. Some types of plants produce Resveratrol and other stilbenes in response to stress, injury, fungal infection, or ultraviolet (UV) radiation. Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration. Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule).
Scientists became interested in exploring potential health benefits of resveratrol in 1992 when its presence was first reported in red wine, leading to speculation that resveratrol might help explain the French Paradox (Good Cardiovascular Health). More recently, reports on the potential for resveratrol to inhibit the development of cancer and extend lifespan in cell culture and animal models have continued to generate scientific interest.
Although trans-resveratrol appears to be well-absorbed by humans when taken orally, its bioavailability is relatively low due to its rapid metabolism and elimination. Resveratrol metabolites are primarily detected upon oral exposure to trans-resveratrol. When six healthy men and women took an oral dose of 25 mg of trans-resveratrol, only traces of the unchanged resveratrol were detected in plasma (blood). Plasma concentrations of resveratrol and metabolites peaked around 60 minutes later at concentrations around 2 micromoles/liter (491 micrograms/liter). A study in 12 healthy men administered an oral dose of 25 mg of trans-resveratrol per 70 kg of body weight reported that serum concentration of resveratrol and metabolites peaked at 30 minutes after administration. The concentration of total resveratrol (resveratrol and metabolites) ranged from 416 to 471 micrograms/liter, depending on whether resveratrol was administered in wine, vegetable juice, or grape juice.
Results of another study suggested that the bioavailability of resveratrol from grape juice, which contains mostly glucosides of resveratrol (piceid), may be even lower than that of trans-resveratrol. A recent study reported that bioavailability of trans-resveratrol from red wine did not differ when the wine was consumed with a meal (low- or high-fat) versus on an empty stomach.
Polyphenol resveratrol has been shown to reduce tumor incidence in animals by affecting one or more stages of cancer development. It has been shown to inhibit growth of many types of cancer cells in culture. Evidence also exists that it can reduce inflammation. It also reduces activation of NF kappa B, a protein produced by the body’s immune system when it is under attack. This protein affects cancer cell growth and metastasis.
Resveratrol is also a great antioxidant to help fight free radical damage in the body. It is quickly absorbed and eliminated from the body so multiple dosages are recommended. Look for resveratrol in capsule, tablet, and bulk powder forms at your local or internet health food store. Look for name brands to ensure you receive a quality and pure product that contains actual trans-resveratrol in each serving.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Resveratrol is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
